ELISA, SPR Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
The original Ab fragment (scFv) was discovered using phage display coupled with size-exclusion chromatography (SEC). Mcl-1 is an important oncology drug target and can crystallizable with antibody fragments as a fusion protein.
Target
Alternative Names
MCL1; myeloid cell leukemia sequence 1 (BCL2-related) ; induced myeloid leukemia cell differentiation protein Mcl-1; BCL2L3; Mcl 1; Bcl 2 related protein EAT/mcl1; Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; BCL2 related; Bcl2-L-3; BCL2L3; EAT; I
Citations
Publication ()
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References
Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1 (myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy, through which normal apoptosis may be restored by inhibiting the protective function of Mcl-1. Here, the discovery and biophysical properties of an anti-Mcl-1 antibody fragment are described and the utility of both the scFv and Fab are demonstrated in generating an Mcl-1 crystal system amenable to iterative structure-guided drug design.
COA
Publication 
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