Anti-MCL1 monoclonal antibody (DCABH-425)

Mouse anti-Human MCL1 monoclonal antibody for WB, IHC-P, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F22
Species Reactivity
Human
Immunogen
Recombinant full length Human MCL1 produced in HEK293T cells (NP_068779)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MCL1; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; BCL2L3; Mcl 1; bcl-2-like protein 3
Entrez Gene ID
UniProt ID

Product Background


Pathway
Apoptosis, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; IL-7 Signaling Pathway, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem;

Citations


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References


Fedorchenko, O; Stiefelhagen, M; et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. BLOOD 121:4126-4136(2013).
Vikstrom, I; Carotta, S; et al. Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory. SCIENCE 330:1095-1099(2010).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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