DENV NS1; Dengue NS1; Dengue Virus non-structural protein 1
Purity
> 90% , as determined by SDS-PAGE
Format
Liquid
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
100 mM Tris HCl pH 8.0; 8M Urea, 200mM NaCl
Preservative
None
Storage
Store at -80°C. Avoid multiple freeze/thaw cycles.
Introduction
NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.
Keywords
Dengue Virus; Non-structural protein; NS1
Citations
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