DENV type 4 Nonstructural Protein 1 [His] (DAG461)

DENV type 4 Nonstructural Protein 1 [His], recombinant protein from E. coli

Product Overview
Recombinant Dengue Type-4 NS1 Protein immunodominant regions, contains a 6-His fusion partner, was expressed in E. coli, and puried in vitro using conventional chromatography techniques.
Nature
Recombinant
Tag/Conjugate
His
Procedure
None
Purity
> 95% pure (12% PAGE (Coomassie)). Proprietary chromatographic technique
Format
Purified, Liquid
Concentration
1.8 mg/ml
Buffer
PBS, pH 7.4
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Caused by one of four closely related virusserotypesof the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholinoantisense oligos have shown specific activity against Dengue virus.
Antigen Description
NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer.
Keywords
Dengue NS1; Dengue Virus non-structural protein 1; DENE; DENE NS1; DEN-2

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