Recombinant Dengue Type-4 NS1 Protein immunodominant regions, contains a 6-His fusion partner, was expressed in E. coli, and puried in vitro using conventional chromatography techniques.
> 95% pure (12% PAGE (Coomassie)). Proprietary chromatographic technique
2-8°C short term, -20°C long term
Caused by one of four closely related virusserotypesof the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholinoantisense oligos have shown specific activity against Dengue virus.
NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer.
Dengue NS1; Dengue Virus non-structural protein 1; DENE; DENE NS1; DEN-2