DENV type 2 Nonstructural Protein 1 (DAG-P2500)

DENV type 2 Nonstructural Protein 1 (aa 776 - 1127), recombinant protein from HEK 293 cells

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Summary
Documentation

Product Overview

Dengue Virus 2 NS1 glycoprotein full length protein

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

40 kDa

Procedure

None

Purity

>95% by SDS-PAGE .This antigen is 0.2μm filter sterilised.

Format

Liquid

Buffer

pH: 7.40Constituent: 100% PBS

Preservative

None

Storage

Shipped on Dry Ice. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 7.40Constituent: 100% PBS

Introduction

The dengue virus (DENV) in one of five serotypes is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. All five serotypes can cause the full spectrum of disease.

Antigen Description

NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.

Keywords

DENV-2 NS1