Mouse Anti-Canine parainfluenza virus monoclonal antibody, clone 9E37

Canine Parainfluenzavirus type 5 (CPIV5) infections is associated with respiratory disease especially in young domestic dogs. The prognosis generally slight or mild when it was alone but mostly had been seeing other respiratory system pathogens. In this study, a total of 94 blood serum samples were collected from clinically healthy and adult (1 to 8 years old) Kangal dogs which are unvaccinated for CPIV in four private Kangal breeding kennels at Ankara province. As a result of evaluation of the sera samples using indirect ELISA, CPIV5 specific antibodies were found to be in 44 (46.8%) dogs. Seropositivity proportions were detected among 33.3% and 63.3% in studied dog kennels. First data for presence and proportion for CPIV5 was obtained with this study in Turkey.

Serum samples from 92 giant pandas in three captive facilities were tested for antibodies against five viruses of carnivores. Antibody titers against canine distemper virus (CDV) in two facilities in which giant pandas were vaccinated were variable. The canine adenovirus (CAV-1) and canine parvovirus (CPV) titers in vaccinated group were both positive, but titers were not high and varied among individual except one vaccinated panda had extremely high CAV-1 titer, indicating infection with the field virus following vaccination. Our results suggest that the vaccines used for these giant pandas do not elicit consistent antibody titers. Antibody titers against CDV, CPV and CAV-1 in unvaccinated giant pandas were highly variable, especially CPV titer. Almost half of sera were CPV antibody positive, and CPV titers were high enough to suggest infection with the virus. Canine coronavirus (CCV) and canine parainfluenza virus (CPIV) titers were not detected in all serum samples. The results of this study emphasize the need for research on infectious diseases of giant pandas and development of suitable vaccines for the species. (C) 2009 Elsevier B.V. All rights reserved,