Cortisol (3) [HRP]

Product Overview

Cortisol linked at the 3-CMO position

Target

Cortisol

Nature

Synthetic

Tag/Conjugate

HRP

Format

Liquid

Buffer

Tris buffer with enzyme stabilizers, pH 7.0

Preservative

0.005% Thimerosal

Storage

Store at 2°C to 8°C

Introduction

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Keywords

Cortisol; Hormones; HRP