Anti-Human Caspase 8 (Cleaved Asp391) monoclonal antibody (CABT-L1217)

Rabbit Anti-Human Caspase 8 (Cleaved Asp391) monoclonal antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
T.258.9
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to residues adjacent to Asp391 of human Caspase-8
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution:
FC: 1:100
ICC: 1:100
IHC-P: 1:100
IF: 1:100
WB: 1:1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Immunohistochemical analysis of Cleaved Caspase-8 (Asp391) in paraffin-embedded human Non-Hodgkin's lymphoma using a Cleaved Caspase-8 (Asp391) monoclonal antibody.
Flow cytometric analysis of Cleaved Caspase-8 (Asp391) in untreated (blue) or etoposide-treated (green) Jurkat cells using a Cleaved Caspase-8 (Asp391) monoclonal antibody compared to a nonspecific negative control antibody (red).

Target


Alternative Names
CASP8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis related cysteine protease; caspase-8; Casp 8; FLICE
Entrez Gene ID
UniProt ID

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Araki, S; Nakayama, Y; et al. Biomarkers for predicting the sensitivity of cancer cells to TRAIL-R1 agonistic monoclonal antibody. CANCER LETTERS 292:269-279(2010).
Liedtke, C; Bangen, JM; et al. Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury. GASTROENTEROLOGY 141:2176-2187(2011).

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