Anti-CASP8 monoclonal antibody, clone 660DU9.6.3

Antibody Isotype

IgG1

Clone

660DU9.6.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:1000-16000

Alternative Names

CASP8; MCH5; Caspase-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; Caspase-8 subunit p18; Caspase-8 subunit p10

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cysteine-aspartic acidprotease (caspase) family. Sequential activation of caspases playsa central role in the execution-phase of cell apoptosis. Caspasesexist as inactive proenzymes composed of a prodomain, a largeprotease subunit, and a small protease subunit. Activation ofcaspases requires proteolytic processing at conserved internalaspartic residues to generate a heterodimeric enzyme consisting ofthe large and small subunits. This protein is involved in theprogrammed cell death induced by Fas and various apoptotic stimuli.The N-terminal FADD-like death effector domain of this proteinsuggests that it may interact with Fas-interacting protein FADD.This protein was detected in the insoluble fraction of the affectedbrain region from Huntington disease patients but not in those fromnormal controls, which implicated the role in neurodegenerativediseases. Many alternatively spliced transcript variants encodingdifferent isoforms have been described, although not all variantshave had their full-length sequences determined. [provided byRefSeq].

Pathway

AGE/RAGE pathway; Activated TLR4 signalling; Activation, myristolyation of BID and translocation to mitochondria; Alzheimer's disease; Alzheimers Disease; Apoptosis; Apoptosis Modulation and Signaling; Apoptosis Modulation by HSP70;