Carazolol [BSA]

The potential mutagenic properties (micronucleus and the Ames tests) of fluoro-A-85380 (2-fluoro-3-[2(S)-2-azetidinylmethoxy] pyridine) were evaluated as a mandatory pre-clinical step. No statistically significant increase in the frequency of micronucleated polychromatic erythrocytes was found in animals treated at any dose tested. No biologically significant increase in the mean number of revertants was noted in all the Salmonella typhimurium strains tested with fluoro-A-85380. Therefore, fluoro-A-85380 demonstrated no mutagenic properties using these two tests. (C) 2002 Elsevier Science Inc. All rights reserved.

Injection of prostaglandin or its analogues has provided a technique to induce parturition after Day 110 of gestation in the gilt (Guthrie, 1985). Alternatively, beta receptor blocker carazolol can be administered alone or in combination with low doses of oxytocin (2.5 IU) (Holtz et al., 1990). Bostedt and Rudloff (1983) reported that carazolol could be used to increase the uterine contraction capability. Similarly, it is also reported that carazolol could be administered to prevent uterine. atony caused by adrenaline reacting with beta receptors in the uterus of cows under stress (Kadir et al., 1990). The aim of this study was to investigate the effects of the beta blocker carazolol on the duration of parturition.