Anti-HMG1 Polyclonal Antibody (CABT-L2096) Knockout Validated

Rabbit Anti-Human HMG1 (Pro9~Arg163) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to human HMGB1 (Pro9~Arg163)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: HMG1 knockout Hela cell lysate. Predicted MW: 25kd, Observed MW: 30kd
Figure. Western Blot. Sample. Lane1: Human Hela Cells; Lane2: Human HepG2 Cells; Lane3: Human Jurkat Cells.

Target


Alternative Names
HMGB1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein
UniProt ID

Product Background


Pathway
Activated TLR4 signalling; Activation of DNA fragmentation factor; Advanced glycosylation endproduct receptor signaling; Apoptosis; Apoptosis induced DNA fragmentation; Apoptotic execution phase; Base excision repair; Cytosolic sensors of pathogen-associated DNA;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Yamada, S; Yakabe, K; et al. New high mobility group box 1 assay system. CLINICA CHIMICA ACTA 372:173-178(2006).
Ueno, H; Matsuda, T; et al. Contributions of high mobility group box protein in experimental and clinical acute lung injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 170:1310-1316(2004).

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