Human SLC30A8 blocking peptide (CDBP2704)

Synthetic Human SLC30A8 blocking peptide for BL

Product Overview
Blocking peptide for anti-Slc30A8 antibody
Target
Slc30A8
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Function
cation transmembrane transporter activity; protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity;
Synonyms
SLC30A8; solute carrier family 30 (zinc transporter), member 8; zinc transporter 8; zinc transporter ZnT-8; ZNT8; ZnT-8;

Citations


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References


Wenzlau, JM; Juhl, K; et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104:17040-17045(2007).
Sorgjerd, EP; Skorpen, F; et al. Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes. Results from the HUNT study, Norway. AUTOIMMUNITY 46:74-79(2013).

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