Human BDNF peptide

Nature

Recombinant

Tag/Conjugate

Unconjugated

Alternative Names

ANON2; BULN2

Format

Purified, Lyophilized Reconstitute using sterile deionized waterto a concentration≥100μg/ml. Further dilutions can be made in other aqueo buffers.

Concentration

1 mg/ml(OD280nm, E0.1% = 1.6) (prior to lyophilization)

Buffer

Lyophilizedfrom 20mM Sodium citrate buffer, pH 5.0

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimers and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

Entrez Gene ID

Antigen Description

Major regulator ofsynaptic transmission and plasticity at adult synapses in many regions of theCNS. The versatility of BDNF is emphasized by its contribution to a range ofadaptive neuronal responses including long-term potentiation (LTP), long-termdepression (LTD), certain forms of short-term synaptic plasticity, as well ashomeostatic regulation of intrinsic neuronal excitability.

Keywords

BDNF; brain-derived neurotrophic factor; ANON2; BULN2; abrineurin; neurotrophin;