Anti-BDNF monoclonal antibody, clone 4E0D6

Antibody Isotype

IgG1

Clone

4E0D6

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human BDNF aa 19-247. Expressed in E. Coli.Sequence: APMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIE ELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLD AANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLE KVPVSKGQLKQ

Conjugate

Application Notes

WB: 1/500 - 1/2000; ICC/IF: 1/200 - 1/1000;

Alternative Names

BDNF; brain-derived neurotrophic factor; neurotrophin; abrineurin; MGC34632;

Entrez Gene ID

UniProt ID

Antigen Description

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Pathway

Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem;