Human POMC blocking peptide (CDBP2400)

Synthetic Human POMC blocking peptide for Apuri, BL, ELISA Datasheet

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Product Overview
Blocking/Immunizing peptide for anti-Proopiomelanocortin/POMC antibody
Proopiomelanocortin / POMC
Species Reactivity
Human, Mouse, Rat
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Lyophilized powder
100 μg
Shipped at ambient temperature, store at -20°C.
UniProt ID
Antigen Description
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
G-protein coupled receptor binding; hormone activity; hormone activity; receptor binding; type 1 melanocortin receptor binding; type 1 melanocortin receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding;
POMC; proopiomelanocortin; pro-opiomelanocortin; ACTH; adrenocorticotropic hormone; adrenocorticotropin; alpha melanocyte stimulating hormone; beta endorphin; beta lipotropin; beta melanocyte stimulating hormone; CLIP; LPH; MSH; NPP; POC; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; corticotropin-lipotropin; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide;


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