Adrenocorticotropic hormone (ACTH), also known as "corticotropin", "Adrenocorticotrophic hormone", is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids and, as its name suggests, cortisol from the adrenal cortex.
Pathway
Adipocytokine signaling pathway; Androgen biosynthesis; Biological oxidations; Class A/1 (Rhodopsin-like receptors); Cytochrome P450 - arranged by substrate type; Endogenous sterols; G alpha (i) signalling events; G alpha (s) signalling events; G-protein activation; GPCR downstream signaling; GPCR ligand binding; Glucocorticoid biosynthesis; Melanogenesis; Metabolism; Metabolism of amino acids and derivatives; Metabolism of steroid hormones and vitamins A and D
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