Adrenocorticotropic hormone (ACTH), also known as "corticotropin", "Adrenocorticotrophic hormone", is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids and, as its name suggests, cortisol from the adrenal cortex.
Pathway
Adipocytokine signaling pathway; Androgen biosynthesis; Biological oxidations; Class A/1 (Rhodopsin-like receptors); Cytochrome P450 - arranged by substrate type; Endogenous sterols; G alpha (i) signalling events; G alpha (s) signalling events; G-protein activation; GPCR downstream signaling; GPCR ligand binding; Glucocorticoid biosynthesis; Melanogenesis; Metabolism; Metabolism of amino acids and derivatives; Metabolism of steroid hormones and vitamins A and D
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Alenazi, FSH; Ibrahim, BA; et al. Estradiol Regulates Effects of Hindbrain Activator 5-Aminoimidazole-4-Carboxamide-Riboside Administration on Hypothalamic Adenosine 5 '-Monophosphate-Activated Protein Kinase Activity and Metabolic Neurotransmitter mRNA and Protein Expression. JOURNAL OF NEUROSCIENCE RESEARCH 93:651-659(2015).
Mobley, CB; Fox, CD; et al. Effects of protein type and composition on postprandial markers of skeletal muscle anabolism, adipose tissue lipolysis, and hypothalamic gene expression. JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION 12:-(2015).
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COA
Certificate of Analysis
