Melanocyte-stimulating hormone belongs to a group called the melanocortins. This group includes ACTH, alpha-MSH, beta-MSH and gamma-MSH; these peptides are all cleavage products of a large precursor peptide called pro-opiomelanocortin (POMC). Alpha-MSH is the most important melanocortin for pigmentation. It increases the pigmentation of skin by increasing melanin production in melanocytes.
Pathway
Adipocytokine signaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; G alpha (s) signalling events; G-protein activation; GPCR downstream signaling; GPCR ligand binding; Glucocorticoid receptor regulatory network; Melanogenesis; Metabolism of amino acids and derivatives; Opioid Signalling; Peptide hormone biosynthesis; Peptide ligand-binding receptors; Signaling by GPCR; Syndecan-3-mediated signaling events
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