Anti-PTBP1 monoclonal antibody, clone 4I9

Antibody Isotype

IgG1

Clone

4I9

Species Reactivity

Human

Immunogen

PTBP1 (NP_002810, 45 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

polypyrimidine tract binding protein 1; Heterogeneous nuclear ribonucleoprotein I; PTB; 57 kDa RNA-binding protein PPTB-1; HNRNP-I; hnRNP I; HNRPI; HNRNPI; PTB-1; MGC10830; PTB2; MGC8461; PTB3; PTB-T; PTB4; heterogeneous nuclear ribonucleoprotein polypept

Entrez Gene ID

UniProt ID

Antigen Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Mouse monoclonal antibody raised against a partial recombinant PTBP1.

Pathway

Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; mRNA Processing, organism-specific biosystem; mRNA Splicing, organism-specific biosystem; mRNA Splicing - Major Pathway, organism-specific biosystem.