Specifications
Species Reactivity
Human; Monkey; Mouse; Rat
Immunogen
Amino acids 477-947 of human NCOA1.
Applications
Application Notes
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 μg/mL) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
nuclear receptor coactivator 1; MGC129719; SRC1; MGC129720; RIP160; OTTHUMP00000155181; bHLHe74; OTTHUMP00000155182; F-SRC-1; OTTHUMP00000201137; KAT13A; bHLHe42; Hin-2 protein; Class E basic helix-loop-helix protein 74; Protein Hin-2; steroid receptor co
Product Background
Antigen Description
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Mouse monoclonal antibody raised against NCOA1.
Pathway
Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem
Citations
Publication ()
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COA
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