NCOA1 (NP_003734, 284 a.a. ~ 393 a.a) partial recombinant protein with GST tag. The sequence is GRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTK CKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPS
Conjugate
Unconjugated
Target
Alternative Names
NCOA1; nuclear receptor coactivator 1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74; Hin-2 protein; PAX3/NCOA1 fusion protein; steroid receptor coactivator-1; renal carcinoma antigen NY-REN-52; class E basic helix-loop-helix protein 74;
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Pathway
Activation of gene expression by SREBF (SREBP); Androgen receptor signaling pathway; Circadian Clock; Energy Metabolism
Citations
Publication ()
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COA
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