Purified from human neutrophils from blood tested and found to be negative for HBs-antigen, anti-HIV1, anti-HIV2, anti-HCV, Lues and GPT. After coating onto ELISA plates the product will bind autoantibodies to myelop eroxidase (pANCA) antigen.
The myeloperoxidase autoantigen is more than 95% pure, as assessed by SDS gel electrophoresis.
The product is stabilised with 0.1% Micr-O-protect TM. Store at -20°C or below (long term) or at +4°C (short term). Avoid repeated freezing and thawing. Mix thoroughly before use.
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene. Myeloperoxidase is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.
chromatin binding; heme binding; heparin binding; metal ion binding; oxidoreductase activity; peroxidase activity;