Myeloperoxidase Antigen

Target

MPO

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

80.4 kDa

Alternative Names

Myeloperoxidase; MPO

Purity

> 95 % as determined by SDS-PAGE

Format

Liquid

Buffer

20 mM PB, 150 mM NaCl, pH7.4

Preservative

None

Storage

Store at -20°C to -80°C

Introduction

Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus and sputum. The green color contributed to its outdated name verdoperoxidase.

Keywords

Myeloperoxidase; MPO; ANCA-associated vasculitis; Microscopic polyangiitis; MPA; MPO-ANCA