Pufferfish Leptin

Name: Pufferfish Leptin
SKU: DAG4592
Rating: 5 (1 reviews)

Pufferfish Leptin, recombinant protein from E. coli

COA

SDS

Datasheet

Summary

Product Overview

Recombinant Pufferfish Leptin

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Sterile filtered, lyophilized

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Leptin, the "satiety hormone", is a hormone made by fat cells which regulates the amount of fat stored in the body. It does this by adjusting both the sensation of hunger, and adjusting energy expenditures. Hunger is inhibited (satiety) when the amount of fat stored reaches a certain level. Leptin is then secreted and circulates through the body, eventually activating leptin receptors in the arcuate nucleus of the hypothalamus. Energy expenditure is increased both by the signal to the brain, and directly via leptin receptors on peripheral targets. The effect of leptin is opposite to that of ghrelin, the "hunger hormone". Ghrelin receptors are on the same brain cells as leptin receptors, so these cells receive competing satiety and hunger signals. Leptin and ghrelin, along with many other hormones, participate in the complex process of energy homeostasis.

Keywords

LEP; leptin; leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , OB, OBS; obese protein; obesity factor; obese, mouse, homolog of; leptin (murine obesity homolog); leptin (obesity homolog, mouse); OB; OBS; FLJ94114;

Citations

Have you cited DAG4592 in a publication? Let us know and earn a reward for your research.

Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

EPB41L4A and LEP gene polymorphisms are associated with antipsychotic-induced QTc interval prolongation in Han Chinese

PSYCHIATRY RESEARCH

Authors: Cao, Haiyan; Li, Shen; Gao, Ying; Ma, Yanyan; Wang, Lili; Chen, Bing; Jiang, Rui; Zhang, Yuan; Li, Weidong; Li, Jie

Abstract

To identify the genetic factors related to antipsychotic-induced QTc interval prolongation (AIQTIP), we analyzed the associations between single nucleotide polymorphisms (SNPs) of candidate genes and quantitative traits of AIQTIP in a Han Chinese population. In total, we collected 112 hospitalized patients suffered from schizophrenia meeting the entry criteria, including 34 first-episode drug-naive patients (FENP). All patients were treated with a single atypical antipsychotic drug (AAPD) for 4 weeks. We analyzed the quantitative genetic association between 10 SNPs in 8 candidate genes and AIQTIP using PLINK software. After 4 weeks of treatment, QTc interval of all patients was significantly prolonged and QTc interval of female patients was significantly longer compared with baseline. Antipsychotics have different effects on the prolongation of QTc. Quetiapine had the most distinct effect on AIQTIP. In all subjects, we found a significant association between the EPB41L4A gene SNP rs7732687 and AIQTIP. In male patients, we also found a significant association between the EPB41L4A gene SNP rs7732687 and AIQTIP. In female patients, we found the LEP gene SNP rs7799039 was significantly associated with AIQTIP. Our results provide preliminary evidence to support the genetic role of EPB41L4A and LEP in AIQTIP.

Consistency of gauged two Higgs doublet model: gauge sector

JOURNAL OF HIGH ENERGY PHYSICS

Authors: Huang, Cheng-Tse; Ramos, Raymundo; Van Que Tran; Tsai, Yue-Lin Sming; Yuan, Tzu-Chiang

Abstract

We study the constraints on the new parameters in the gauge sector of gauged two Higgs doublet model using the electroweak precision test data collected from the Large Electron Positron Collider (LEP) at and off the Z-pole as well as the current Drell-Yan and high-mass dilepton resonance data from the Large Hadron Collider (LHC). Impacts on the new parameters by the projected sensitivities of various electroweak observables at the Circular Electron Positron Collider (CEPC) proposed to be built in China are also discussed. We also clarify why the Stueckelberg mass M-Y for the hypercharge U(1)(Y) is set to be zero in the model by showing that it would otherwise lead to the violation of the standard charge assignments for the elementary quarks and leptons when they couple to the massless photon.