This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function
ATP binding; NF-kappaB-inducing kinase activity; interleukin-1 receptor binding; kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; ubiquitin-protein transferase activity
Synonyms
IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog
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