Specificity
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the hexokinase family.
Alternative Names
The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose a
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
Function
ATP binding; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; mannokinase activity;
Synonyms
HK2; hexokinase 2; HKII; HXK2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase;
Citations
Publication ()
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COA
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