Anti-HK2 monoclonal antibody, clone 2F9-I4-G22

Antibody Isotype

IgG1

Clone

2F9-I4-G22

Species Reactivity

Mouse; Rat; Human; Pig

Immunogen

Purified recombinant fragment derived from the N terminal of Human Hexokinase II expressed in E. coli (NM_000189).

Conjugate

Application Notes

WB: 1/1000; Flow Cyt: 1/100;

Alternative Names

HK2; hexokinase 2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase; HKII; HXK2; DKFZp686M1669;

Entrez Gene ID

UniProt ID

Antigen Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Pathway

Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Butirosin and neomycin biosynthesis, organism-specific biosystem; Butirosin and neomycin biosynthesis, conserved biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem; Fructose and mannose metabolism, organism-specific biosystem;