Anti-HK2 monoclonal antibody, clone 4E4

Antibody Isotype

IgG1

Clone

4E4

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human HK2.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Flow Cytometry (1:200-1:400) & The optimal working dilution should be determined by the end user.

Alternative Names

HK2; hexokinase 2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase; HKII; HXK2; DKFZp686M1669;

Entrez Gene ID

UniProt ID

Antigen Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Pathway

Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Butirosin and neomycin biosynthesis, organism-specific biosystem; Butirosin and neomycin biosynthesis, conserved biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem; Fructose and mannose metabolism, organism-specific biosystem;