Anti-HK2 monoclonal antibody

Antibody Isotype

IgG2a

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment: IVKEVCTVVA RRAAQLCGAG MAAVVDRIRE NRGLDALKVT VGVDGTLYKL HPHFAKVMHE TVKDLAPKCD VSFLQSEDGS GKGAALITAV ACRIREAGQR, corresponding to amino acids 818-917 of Human Hexokinase IIwith a proprietary tag (MW of the tag alone is 26 KDa).

Conjugate

Application Notes

WB: 1/500 - 1/1000; Flow Cyt: 0.5μg/10⁶ cells;

Alternative Names

HK2; hexokinase 2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase; HKII; HXK2; DKFZp686M1669;

Entrez Gene ID

UniProt ID

Antigen Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Pathway

Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Butirosin and neomycin biosynthesis, organism-specific biosystem; Butirosin and neomycin biosynthesis, conserved biosystem; Carbohydrate digestion and absorption, organism-specific biosystem; Carbohydrate digestion and absorption, conserved biosystem; Fructose and mannose metabolism, organism-specific biosystem;