Product Overview
Blocking peptide for Hec1 (phospho Ser 55) antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Storage
Store at -20°C. Avoid repeated freeze/thaw cycles.
Antigen Description
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Function
protein binding;
Synonyms
NDC80; NDC80 kinetochore complex component; HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80; kinetochore protein NDC80 homolog; kinetochore associated 2; kinetochore protein Hec1; kinetochore-associated protein 2; highly expressed in cancer protein; retinoblastoma-associated protein HEC; NDC80 kinetochore complex component homolog; NDC80 homolog, kinetochore complex component; highly expressed in cancer, rich in leucine heptad repeats;
Citations
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Wei, RR; Sorger, PK; et al. Molecular organization of the Ndc80 complex, an essential kinetochore component. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102:5363-5367(2005).
Du, J; Cai, X; et al. The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. ONCOGENE 27:4107-4114(2008).