Specifications
Species Reactivity
Mouse; Human; Pig; African green monkey; Chinese Hamster
Immunogen
Recombinant protein encoding amino acids 56-642 of human HEC 1 purified from E. coli.
Applications
Application Notes
Flow Cyt: 1μg/106 cells; WB: 1/1000.
Target
Alternative Names
NDC80; NDC80 kinetochore complex component homolog (S. cerevisiae); highly expressed in cancer, rich in leucine heptad repeats (yeast) , kinetochore associated 2 , KNTC2; kinetochore protein NDC80 homolog; HEC; HEC1; hsNDC80; TID3; kinetochore associated
Product Background
Antigen Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
Pathway
Aurora B signaling, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; Mitotic Prometaphase, organism-specific biosystem.
Citations
Publication ()
Have you cited DCABH-8753 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
