Tag/Conjugate
Unconjugated
Purity
> 95 % by SDS-PAGE.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Reconstitution
NDC80 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.
Introduction
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Synonyms
NDC80; NDC80 kinetochore complex component; HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80; kinetochore protein NDC80 homolog; kinetochore associated 2; kinetochore protein Hec1; kinetochore-associated protein 2; highly expressed in cancer protein; retinoblastoma-associated protein HEC; NDC80 kinetochore complex component homolog; NDC80 homolog, kinetochore complex component; highly expressed in cancer, rich in leucine heptad repeats;
Citations
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McCleland, ML; Gardner, RD; et al. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. GENES & DEVELOPMENT 17:101-114(2003).
Wei, RR; Sorger, PK; et al. Molecular organization of the Ndc80 complex, an essential kinetochore component. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102:5363-5367(2005).