Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs. Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. The function about GUCY1B3 antigen include GTP binding, guanylate cyclase activity, heme binding, Hsp90 protein binding, ion binding, lyase activity, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity, protein heterodimerization activity, receptor activity.