Objectives: To describe the characteristics and clinical differences between institutionalised patients and those included in a home care program. Design: A descriptive, observational, cross-sectional, and multicentre study. Site Seville, 2016. Study subjects: A total 1857 elderly patients of similar characteristics (1441 institutionalised and 416 at home) in Seville in 2016. Measurements: The variables studied included gender, age, civil status, family support, pathologies, multiple pathology criteria, and medication prescriptions. Functional and cognitive status was evaluated using the Barthel index, and the Lawton-Brody and Pfeiffer scales. Results: The majority of patients (71.40%) were women. The fact of being institutionalised or being included in a home care program were statistically related to the following pathologies and categories: schizophrenia (p < .001), arterial hypertension (p = .012), diabetes mellitus (p = .001), atrial fibrillation (p < .001), and neoplasia (p = .012), A1 (p = .012), A2 (p < .001), B1 (p < .001), B2 (p = .002), C (p < .001), E1 (p < .001), E3 (p = .01), F2 (p < .01), G2 (p = .024), and H (p= .005). The mean Barthel index of the sample was 49.1 +/- 34.45 (95% confidence interval: 47.49-50.7). The mean Lawton-Brody scale in the case of patients included the home care program was 2.33 +/- 2.49 and in those institutionalised 1.59 +/- 2.12. The mean Pfeiffer scale was 4.93 +/- 3.53. Conclusions: Cognitive impairment was related to institutionalisation, being a result of possible neurological (E3 category) and psychiatric diseases. On the other hand, patient comorbidity was not related to it, because it is very high in patients included in a home care program, in whom functional and cognitive independency status is better. (C) 2019 Published by Elsevier Espana, S.L.U.