Product Overview
Blocking/Immunizing peptide for anti-CRIPTO antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Function
growth factor activity; protein binding; receptor binding;
Synonyms
TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;
Citations
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Adewumi, O; Aflatoonian, B; et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. NATURE BIOTECHNOLOGY 25:803-816(2007).
Fang, ZF; Gai, H; et al. Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos. EXPERIMENTAL CELL RESEARCH 312:3669-3682(2006).