Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Mouse Cripto shares 66% and 34% amino acid identity with human Cripto and zebrafish one-eyed pinhead (OEP), respectively. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling.
Pathway
Developmental Biology; Glypican 1 network; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Regulation of signaling by NODAL; Signaling by NODAL; Transcriptional regulation of pluripotent stem cells;
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