Human CBL blocking peptide

Aim To evaluate and compare radiographic crestal bone loss (CBL) and soft tissue parameters around submerged/two-stage and nonsubmerged/one-stage single implants with the same endosseous portion (body design and surface, thread design and distance) and identical intramucosal laser-microgrooved surface, after 3 years of loading. Materials and methods Twenty submerged/two-stage implants and 20 nonsubmerged/one-stage implants were placed randomly with a split-mouth design in the posterior areas of 20 partially edentulous patients. Radiographic and clinical examinations were carried out at the implant placement, at the delivery of prosthetic restorations, and at each year of the follow-up period. Plaque index (PI), probing depth (PD), bleeding on probing (BOP), and gingival recession (REC) were recorded. Radiographic crestal bone levels were assessed at the mesial and distal aspect of the implant sites. In addition, the influence of the vertical keratinized tissue thickness (KTT) on CBL was investigated. Results At the delivery of prosthetic restorations, a statistically significant difference (P = 0.013) was found in radiographic mean CBL between submerged and nonsubmerged implants (0.15 +/- 0.05 mm vs. 0.11 +/- 0.04 mm). At the end of the follow-up period, no statistical difference (P = 0.741) was found in the mean CBL between submerged and nonsubmerged implants (0.27 +/- 04 mm vs. 0.26 +/- 0.5 mm). The changes in the soft tissues including PI, PD, BOP, and REC had no significant differences in either group. Moreover, KTT did not show a statistical correlation with CBL. Conclusions After 3 years of loading, no statistical difference was noted in CBL and soft tissue conditions between single submerged two-stage and nonsubmerged one-stage laser-microgrooved implants.

Background It is unknown whether cone beam computed tomography (CBCT) image reconstruction characteristics, including section thickness, may affect linear bone measurements of periodontal intrabony defects. The aim of this study was to compare intrasurgical and CBCT-based linear measurements of intrabony defects focusing on CBCT section thickness. Methods Sixty-six intrabony defects were assessed in 21 patients with chronic generalized severe periodontitis. Linear measurements of alveolar bone (radiographic bone level [rBL]), assessed in CBCT images at diverse section thicknesses: 0.25 mm (voxel size), 1 mm, and 3 mm, were compared with clinical bone level (cBL) measurements obtained intrasurgically. To provide identical reference points for rBL and cBL measurements, individually adjusted grooves on the reference stent were prepared for each periodontal defect site. CBCT measurements were performed in two rounds by two trained observers. Observer agreement was assessed by intraclass correlation coefficients (ICC). ANOVA assessed the difference among cBL and rBL at different section thicknesses. Results Intra- and inter-observer agreement was excellent (ICC >0.99) and highly significant independent of the observer, evaluation round, and CBCT section thickness. Mean rBL in the diverse CBCT section thicknesses was very close to that measured clinically (cBL). There was no statistically significant difference between cBL and rBL for any section thickness, neither for the overall evaluated sites, nor the maxilla or mandible separately. Conclusions No statistically significant difference between clinical and radiographic bone level for 0.25-, 1-, and 3-mm CBCT section thicknesses were observed when assessing intrabony periodontal defects.