Rabbit Anti-Human CBL (Phospho-Tyr731) polyclonal antibody

T-cell receptor (TCR) ligation-mediated protein phosphorylation regulates the activation, cellular responses, and fates of T cells. Here, we used time-resolved high-resolution phosphoproteomics to identify, quantify, and characterize the phosphorylation dynamics of thousands of phosphorylation sites in primary T cells during the first 10 min afterTCRstimulation. Bioinformatic analysis of the data revealed a coherent orchestration of biological processes underlying T-cell activation. In particular, functional modules associated with cytoskeletal remodeling, transcription, translation, and metabolic processes were mobilized within seconds afterTCRengagement. Among proteins whose phosphorylation was regulated byTCRstimulation, we demonstrated, using a fast-track gene inactivation approach in primary lymphocytes, that theITSN2 adaptor protein regulated T-cell effector functions. This resource, called LymphoAtlas, represents an integrated pipeline to further decipher the organization of the signaling network encoding T-cell activation. LymphoAtlas is accessible to the community at: .

Here, we report a luminescent cathode buffer layer (CBL) for power conversion efficiency (PCE) enhancement of organic solar cells (OSCs). ZnO doped with Aluminum (Al) and Europium (Eu) was cast as CBL by a solution-processed method. CBL serves a dual purpose by acting both as a spectral conversion and an electron transporting layer. The luminescent ZnO:Al,Eu CBL layer has broad absorption spanning the ultraviolet (300-400 nm) spectrum, contributing to absorption enhancement. Moreover, the emission of CBL layer overlaps with the absorption of poly [N -9'-heptadecanyl-2,7-carbazole- alt-5,5-(4',7'-di-2-thienyl-2',1',3'-benzothiadiazole)] (PCDTBT) polymer thus elevating the overall absorption of the active layer and improving the photocurrent With this ZnO:Al,Eu CBL in the inverted device configuration (ITO/CBL/active layer/MoOx/Al), an enhanced power conversion efficiency (PCE) of 6.9% was obtained while the device with pristine ZnO as CBL showed PCE of 5.9%. A blend of PCDTBT donor and [6,6]-phenyl C-71 butyric acid methyl ester (PC71BM) acceptor was used as an active layer in both the cases. In ZnO:Al,Eu CBL layer, Al doping improves the conductivity, while Eu doping significantly enhances the emission in the visible region by down-shifting the incoming solar UV light to the visible range which overlaps with the absorption of PCDTBT polymer resulting in energy transfer and improved overall device efficiency. The findings of the study show the significance of luminescent znO:ALEu nanoparticle CBL in enhancing the performance of organic solar cells.