Human BACE2 blocking peptide (CDBP0551)

Synthetic Human BACE2 blocking peptide for BL

Product Overview
BACE 2 ( C - term ) peptide ( human )
Target
BACE2
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Procedure
None
Concentration
0.2 mg/ml
Size
50 μg
Buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Preservative
0.02% Sodium Azide
Storage
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.
UniProt ID
Antigen Description
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
Function
aspartic-type endopeptidase activity; peptidase activity;
Synonyms
BACE2; beta-site APP-cleaving enzyme 2; AEPLC; beta-secretase 2; ALP56; CEAP1; DRAP; asp 1; memapsin-1; theta-secretase; beta secretase 2; aspartyl protease 1; 56 kDa aspartic-like protease; aspartic-like protease 56 kDa; down region aspartic protease; beta-site APP cleaving enzyme 2; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid precursor protein cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; ASP1; BAE2; ASP21; CDA13;

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References


Vats, D; Wang, H; et al. Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27). DIABETOLOGIA 55:2407-2416(2012).
Atwal, JK; Chen, YM; et al. A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-beta Production in Vivo. SCIENCE TRANSLATIONAL MEDICINE 3:-(2011).

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