Anti-BACE2 (aa 306-395) polyclonal antibody

Species Reactivity

Human

Immunogen

BACE2 (NP_036237, 306 a.a. ~ 395 a.a) partial recombinant protein with GST tag. The sequence is TTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDE NSSRSFRITILPQLYIQPMMGAGLNYECYR

Conjugate

Alternative Names

BACE2; beta-site APP-cleaving enzyme 2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; beta-secretase 2; memapsin-1; theta-secretase; aspartyl protease 1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; transmembrane aspartic

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimers disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.

Pathway

Alzheimers disease;