Anti-ssDNA monoclonal antibody (DMAB23910)

Mouse anti-Bovine ssDNA monoclonal antibody for FC, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgM
Clone
G8-37
Species Reactivity
Bovine
Conjugate
Unconjugated

Target


Alternative Names
Singal strand DNA; Mouse Anti-ssDNA Monoclonal Antibody; Anti-ssDNA Monoclonal Antibody; ssDNA Monoclonal Antibody Mouse Anti-ssDNA MAb; Anti-ssDNA MAb; ssDNA MAb

Product Background


Antigen Description
most DNA molecules are actually two polymer strands, bound together in a helical fashion by noncovalent bonds; this double stranded structure (dsDNA) is maintained largely by the intrastrand base stacking interactions, which are strongest for G,C stacks. The two strands can come apart – a process known as melting – to form two ssDNA molecules. Melting occurs when conditions favor ssDNA; such conditions are high temperature, low salt and high pH (low pH also melts DNA, but since DNA is unstable due to acid depurination, low pH is rarely used).

Citations


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References


Nimse, SB; Song, KS; et al. 9G DNAChip Technology: Self-Assembled Monolayer (SAM) of ssDNA for Ultra-Sensitive Detection of Biomarkers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 14:5723-5733(2013).
Levite, M; Hermelin, A; et al. Autoimmunity to the glutamate receptor in mice - A model for Rasmussen's encephalitis?. JOURNAL OF AUTOIMMUNITY 13:73-82(1999).

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