Recombinant fragment corresponding to Human U2AF65 aa 277-454. BC008740Sequence: ELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLG DKKLLVQRASVGAKNATLSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCL MNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCG KIFVEFTSVFDCQKAMQGLTG
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/100 - 1/500; WB: 1/200 - 1/1000;
Target
Alternative Names
U2AF2; U2 small nuclear RNA auxiliary factor 2; U2AF65; splicing factor U2AF 65 kDa subunit; hU2AF65; U2 auxiliary factor 65 kDa subunit; U2 snRNP auxiliary factor large subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 small nuclear ribonucleop
Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.
Pathway
Cleavage of Growing Transcript in the Termination Region; Processing of Capped Intron-Containing Pre-mRNA; RNA Polymerase II Transcription Termination; Spliceosome
Citations
Publication ()
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