Anti-U2AF2 monoclonal antibody, clone ND4

Antibody Isotype

IgG2b

Clone

ND4

Species Reactivity

Mouse; Rat; Human; Xenopus laevis

Immunogen

Recombinant full length protein (Human)

Conjugate

Application Notes

WB: 0.1 - 0.2 μg/ml;

Alternative Names

U2AF2; U2 small nuclear RNA auxiliary factor 2; U2 (RNU2) small nuclear RNA auxiliary factor 2; splicing factor U2AF 65 kDa subunit; splicing factor U2AF 65 kD subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 snRNP auxiliary factor

Entrez Gene ID

UniProt ID

Antigen Description

Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.

Pathway

Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem;