Anti-U2AF2 monoclonal antibody, clone 6H9

Antibody Isotype

IgG1

Clone

6H9

Species Reactivity

Human

Immunogen

U2AF2 (NP_001012496.1, 141 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

U2AF2; U2 small nuclear RNA auxiliary factor 2; U2 (RNU2) small nuclear RNA auxiliary factor 2; splicing factor U2AF 65 kDa subunit; splicing factor U2AF 65 kD subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 snRNP auxiliary factor

Entrez Gene ID

UniProt ID

Antigen Description

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Pathway

Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem;