Anti-TLE4 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human TLE4 is used for rabbit immunization.

Conjugate

Alternative Names

TLE4; transducin-like enhancer of split 4; ESG; BCE1; ESG4; GRG4; BCE-1; E(spI); transducin-like enhancer protein 4; B lymphocyte gene 1; enhancer of split groucho 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhanc

Entrez Gene ID

UniProt ID

Antigen Description

TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES. Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Pathway

Disease; FBXW7 Mutants and NOTCH1 in Cancer; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1; Signaling by NOTCH1 HD Domain Mutants in Cancer; Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer; Signaling by NOTCH1 PEST Domain Mutants in Cancer; Signaling by NOTCH1 in Cancer;