Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Pathway
Disease; FBXW7 Mutants and NOTCH1 in Cancer; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1; Signaling by NOTCH1 HD Domain Mutants in Cancer;
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