Specifications
Immunogen
Synthetic peptide: NSLSLAQRRGFTKTY by a Cysteine residue linker, corresponding to internal sequence amino acids 129-143 of Human TIMP1 (NP_003245.1)
Applications
Application Notes
WB: 0.1 - 0.3 μg/ml.
Target
Alternative Names
TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO; TIMP-1; collagenase inhibitor; erythroid potentiating activity; ery
Product Background
Antigen Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Pathway
Activation of Matrix Metalloproteinases; Degradation of the extracellular matrix; Extracellular matrix organization; Hemostasis; IL6-mediated signaling events; Matrix Metalloproteinases; Platelet activation, signaling and aggregation
Citations
Publication ()
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COA
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