Anti-TIMP1 polyclonal antibody (DPABH-22955)

Specifications


Host Species
Goat
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide: NSLSLAQRRGFTKTY by a Cysteine residue linker, corresponding to internal sequence amino acids 129-143 of Human TIMP1 (NP_003245.1)
Conjugate
Unconjugated

Applications


Application Notes
WB: 0.1 - 0.3 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TIMP1; TIMP metallopeptidase inhibitor 1; CLGI, TIMP, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); metalloproteinase inhibitor 1; EPO; TIMP-1
Entrez Gene ID
UniProt ID

Product Background


Pathway
Activation of Matrix Metalloproteinases; Degradation of the extracellular matrix; Extracellular matrix organization; Hemostasis; IL6-mediated signaling events; Matrix Metalloproteinases; Platelet activation, signaling and aggregation

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Mohammed, FF; Smookler, DS; et al. Abnormal TNF activity in Timp3(-/-) mice leads to chronic hepatic inflammation and failure of liver regeneration. NATURE GENETICS 36:969-977(2004).
Dien, J; Amin, HM; et al. Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer. AMERICAN JOURNAL OF PATHOLOGY 169:633-642(2006).

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