Anti-TIMP1 polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Rat

Immunogen

Mouse myeloma cell line NS0-derived recombinant rat TIMP-1. Cys24-Ala217 Accession Number P30120

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4111 - DPABY-437

Alternative Names

TIMP1; TIMP metallopeptidase inhibitor 1; Timp; TIMP-1; metalloproteinase inhibitor 1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1;

Entrez Gene ID

UniProt ID

Antigen Description

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Pathway

Activation of Matrix Metalloproteinases; Degradation of the extracellular matrix; Extracellular matrix organization; HIF-1 signaling pathway; Hemostasis; Matrix Metalloproteinases; Platelet activation, signaling and aggregation; Platelet degranulation;