Synthetic peptide from the unique amino-terminal end of the protein, conjugated to KLH (peptide was post-synthetically modified to achieve highest antigenicty before used for coupling to KLH using heterobifunctional cross linker).
Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
Pathway
Activated TLR4 signalling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; IKK complex recruitment mediated by RIP1; IL1-mediated signaling events; IRAK2 mediated activation of TAK1 complex; Immune System; Innate Immune System
Citations
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