Anti-THC monoclonal antibody, clone N2800UID3

OBJECTIVE:This article presents proven, promising, and potential therapeutic uses for cannabidiol (CBD) in the treatment of psychiatric and neurologic conditions and diseases. It presents popular, but scientifically unproven health and therapeutic claims of CBD supporting the beneficial homeostatic effects of the intrinsic or endogenous cannabinoid system. It includes a review of cannabinoid pharmacology; it compares properties and the legal status of CBD and THC (delta 9-tetrahydrocannabinol) as well as the hemp and marijuana varieties ofCannabis, and it reviews the historic 2018 U.S. Food and Drug Administration approval of Epidiolex, an oral solution of cannabidiol for two rare treatment-resistant childhood epilepsies, as the firstCannabis-derived drug.METHOD:We reviewed literature on cannabidiol, CBD, the endocannabinoid neuropharmacology system, and hemp and marijuana varieties ofCannabis sativa.RESULTS:The proven and promising medical uses and deficiencies of unproven health claims for CBD, legal implications forCannabis-derived drugs, and comparisons of CBD and THC and hemp and marijuana are summarized objectively with pertinent references.CONCLUSION:CBD and CBD and THC combinations have potential to provide safe, effective therapy for several psychiatric and neurologic conditions and diseases. However, such achievement will require a uniform standard of CBD purity and strength, and corroboration from adequately large and rigorously controlled clinical research studies.

Biofuels provide high oxygen content for combustion and do modify properties that influence the engine operation process such as viscosity, enthalpy of vaporization, and cetane number. Some requirements of performance, fuel consumption, efficiency, and exhaust emission are necessary for the validation of these biofuels for application in engines. This work studies the effects of the use of diethyl ether (DEE) in biodiesel-ethanol blends in a DI mechanical diesel engine. The blends used in the tests were B80E20 (biodiesel 80%-ethanol 20%) and B76E19DEE5 (biodiesel 76%-ethanol 19%-DEE 5%). Fossil diesel (D100) and biodiesel (B100) were evaluated as reference fuels. The results revealed similar engine efficiencies among tested fuels at all loads. The use of B100 increased CO and NO(x)and decreased THC compared to D100 at the three loads tested. B80E20 fuel showed an increase in NO(x)emission in comparison with all fuels tested, which was attributed to higher oxygen content and lower cetane number. THC and CO were also increased for B80E20 compared to B100 and D100. The use of B76E19DEE5 fuel revealed reductions in NO(x)and CO emissions, while THC emissions increased. The engine efficiency of B76E19DEE5 was also highlighted at intermediate and more elevated engine load conditions.