Anti-SUMO2 monoclonal antibody, clone 084DU9.2.2

Antibody Isotype

IgG2b

Clone

084DU9.2.2

Species Reactivity

Human; Rat

Conjugate

Application Notes

WB: 1:1000

Alternative Names

SUMO2; SMT3A; SMT3H2; Small ubiquitin-related modifier 2; Small ubiquitin-related modifier 2; HSMT3; Small ubiquitin-related modifier 2; SMT3 homolog 2; Small ubiquitin-related modifier 2; SUMO-3; Small ubiquitin-related modifier 2; Sentrin-2; Small u

Entrez Gene ID

UniProt ID

Antigen Description

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

Pathway

Conjugation of SUMO to E1 (UBA2:SAE1); Glucocorticoid receptor regulatory network; Metabolism of proteins; Nuclear pore complex; Post-translational protein modification; Processing and Activation of SUMO; Proteolytic Processing of SUMO; RNA transport;